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Bridging the Terahertz Gap
Modeling the Lithium-Ion Battery
Corrosion Protection
Battery Modeling
Modeling and Simulation in Fuel Cell Development

Explicit Dosimetry for Photodynamic Therapy; Singlet Oxygen Modeling based on Finite-Element Method

Ken Kang-Hsin Wang[1], and Timothy C. Zhu[1]
[1]Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Published in 2009

Singlet oxygen (¹O₂) is the major cytotoxic agent during type-II photodynamic therapy (PDT). The production of ¹O₂ involves the complex reactions among cancer agent, oxygen molecule, and treatment laser light. The light propagation in tumor tissue is described by the diffusion equation. In this work, an optimization routine is developed to fit the [¹O₂]_rx profile to the simulated necrosis distance. In this work, a COMSOL based singlet oxygen model is developed for photodynamic therapy.

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